دواء سيدنا ايوب 

Published by Wael Baseem · January 13 ·

 

اضرب برجلك هذا مفتسل بارد وشراب

Portulaca oleracea

How Ayoub the prophet was cured 

كيف شفي ايوب عليه السلام

الرجلة أو البَقْلَة 

اركض برجلك هذا :

١- مغتسل بارد

٢- شراب

نقطه

الرجله المباركه، لاتمو الا في ممرات السيول والانهار

ابن سينا فيقول: إنها تقلع التآليل 

داود الانطاكي فيقول: إن من فوائدها أنها تمنع الصداع والأورام الحارة والرمد والحكة والجرب 

وكذلك ترياق للدغات الآفاعي والعقارب والرتيلاء، كما تستخدم كدهان لعلاج المشاكل الجلدية

باركها الرسول صلى الله عليه وآله وأحبتها البتول …

وروي أن النّبيّ (صلى الله عليه وآله) وجد حرارةً فعضّ على رجلة فوجد لذلك راحةً، فقال: «اللّهمّ بارك فيها، إنّ فيها شفاءً من تسعة وتسعين داء، انبتي حيث شئت»[2].

حيث انها مضاده للعطش وقابضه وتعلاج امراض الجلد المستعصيه المشهور بها بني اسرائيل 

تعتبر منذ القدم بأنها أفضل النباتات الطبية , ومما قيل عنها : إنها تمنع الصداع ,

والرمد , والحكة , والجرب , وبذر هذا النبات يغلى في الماء فيطرد الدودة الوحيدة .

وقد أكدت أحدث الدراسات العلمية أن نبات الرجلة له دور فعال فى الوقاية من السرطان وعلاجه، حيث إنه يعمل على منع نمو وتكاثر الخلايا السرطانية، ويقوم بالتقاط الشوارد الحرة الناتجة عن الإصابة بالسرطان فيحد من انتشاره.

اعتبرت البقلة ولفترة طويلة نباتًا طبيًّا حيث أنها تحتوي على نسبة بيتا كاروتين عالية أكثر من السبانخ، بالإضافة إلى المستويات العالية للمغنيسيوم والبوتاسيوم وفيتامين أ، وج، واستعملت لمعالجة أوجاع الرأس والمثانة ولشفاء القروح ولطرد الديدان ولشفاء ضربة البرد والإصابات بمسحوق البارود. وبشكل عام فقد استخدمت تاريخيًّا كعلاج للروماتيزم.

وتستعمل أزهار وأوراق البقلة لمعالجة أمراض كثيرة ومنها : التهابات الجلد، والاكزيما، والباسور، والتهابات في المسالك البولية والرئتين ولتحضير الضمادات ضد الحروق، فقد بينت الدراسات التي أجريت في المختبرات أن البقلة تحوي مواد مضادة للجراثيم والفطريات.

تستعمل البقلة هذه الأيام لتنقية الدم ومعالجة التهابات اللثة وذلك عن طريق مضغها.

في الطب التقليدي، استخدمت البقلة لإزالة الحرارة والمواد السامة، وإيقاف النزيف، إضافة لاستخدامها في علاج أمراض التنفس.

نطلب من الازهر الشريف ودار الافتاء بتصحيح تفسير القران في الايتين

١-

فَادْعُ لَنَا رَبَّكَ يُخْرِجْ لَنَا مِمَّا تُنبِتُ الْأَرْضُ مِن بَقْلِهَا 

٢-

ارْكُضْ بِرِجْلِكَ ۖ هَٰذَا مُغْتَسَلٌ بَارِدٌ وَشَرَابٌ 

.

علي اساس ان البقله المشار اليها هي البقله الحمراء او نبات الرجله

وعلي اساس ان كلمه برجلك هذا ، ، لاتعني ابدا برجليك ولا بارجلك ولا قدميك حتي فهي تشير الي نبات الرجله الذي يعالج الجرب والصدفيه كمغتسل بارد والديدان المعويه كشراب مستخرج لتعم المنفعه علي الناس بدلا من شركات الدواء وانتشار الوباء القادم.

Chemical constituents

noradrenaline, calcium salts, dopamine, L-DOPA, malic acid, citric acid, glutamic acid, asparagic acid, nicotinic acid, alanine, glucose, fructose, and sucrose.^[16] Purslane also contains oxalic acid that makes it non-recommended in large quantities for people who have uric acid or kidney problems or must restrict dietary oxalate levels.^[17]

Betacyanins isolated from Portulaca oleracea improved cognition deficits in aged mice.^[18] A subclass of homoisoflavonoids from the plant showed in vitro cytotoxic activities towards four human cancer cell lines.^[19]

Niutrition

Purslane contains more omega-3 fatty acids (alpha-linolenic acid in particular^[13]) than any other leafy vegetable. Studies have found that purslane has 0.01 mg/g of eicosapentaenoic acid (EPA). It also contains vitamins (mainly vitamin A, vitamin C, vitamin E (alpha-tocopherol),^[14] vitamin B, carotenoids), and dietary minerals such as magnesium, calcium, potassium, and iron.

Also present are two types of betalain alkaloid pigments, the reddish betacyanins (visible in the coloration of the stems) and the yellow betaxanthins(noticeable in the flowers and in the slight yellowish cast of the leaves). Both of these pigment types are potent antioxidants and have been found to have antimutagenic properties in laboratory studies.^[15]

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Portulaca oleracea L.: A Review of Phytochemistry and Pharmacological Effects

 

1. Introduction

Portulaca oleracea L. is a warm-climate, herbaceous succulent annual plant with a cosmopolitan distribution belonging to the Portulacaceae family. It is commonly known as purslane (USA and Australia), rigla (Egypt), pigweed (England), pourpier (France), and Ma-Chi-Xian (China) [1]. It is distributed widely in the tropical and subtropical areas of the world including many parts of the United States and is eaten extensively as a potherb and is added to soups and salads around the Mediterranean and tropical Asian countries [2]. Americans and aborigines of Australia grind the seeds of this plant into flour for use in mush and bread [3]. Portulaca oleracea also provides a source of nutritional benefits owing to its rich omega-3 fatty acids and antioxidant properties [4].

Portulaca oleracea has been used as a folk medicine in many countries, acting as a febrifuge, antiseptic, vermifuge, and so forth [5]. It exhibits a wide range of pharmacological effects, including antibacterial [6], antiulcerogenic [7], anti-inflammatory [8], antioxidant [9], and wound-healing [10] properties. It is listed by the World Health Organization as one of the most used medicinal plants, and it has been given the term “Global Panacea” [11]. The Chinese folklore described it as “vegetable for long life” and it has been used for thousands of years in traditional Chinese Medicine [12, 13]. It is cold in nature and sour in taste and is used to cool the blood, stanch bleeding, clear heat, and resolve toxins. The dried aerial part of this plant is indicated for the treatment of fever, dysentery, diarrhoea, carbuncle, eczema and hematochezia, with a recommended dose of 9–15 g [14–16].

Portulaca oleracea has a high potential to be used as human and animal food and to be utilized as a pharmacological agent in medicine. In this paper, phytochemistry and pharmacological activities of this plant are reviewed and its potential for further investigation, exploitation, and utilization are discussed.

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2. Phytochemistry

Many constituents of Portulaca oleracea have been isolated, including flavonoids, alkaloids, fatty acids, terpenoids, polysaccharides, vitamins, sterols, proteins, and minerals; these are listed in Table 1 and the chemical structures of the main compounds are presented in Figure 1.

 

 

 

Compounds isolated from purslane.

 

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One of the most effective constituents present in Chinese Herbal Medicines are flavonoids which are biologically active and possess a wide range of pharmacological properties such as antibacterial, antivirus, anti-inflammation, and antioxidation properties. In the Portulaca oleracea plant, the flavonoids levels vary according to the part of the plant; the highest levels are present in the root followed by stem and the leaf; and seven different flavonoids are present in this plant, including kaempferol, myricetin, luteolin, apigenin, quercetin, genistein, and genistin [17]. However, only kaempferol and apigenin have been found in ethanolic extracts of leaves and stems, with the levels in the former being higher [11]. Portulacanones B–D, three homoisoflavonoids compounds, display selectively cytotoxic activities against three human cancer cell lines (SF-268, NCI-H460, and SGC-7901) [18]. Flavonoids are also widely present in foods such as fruits and vegetables [19].

In addition to flavonoids, another important chemical found in this plant is alkaloids including dopa, dopamine, and noradrenalin. The content of dopamine and noradrenalin is higher in leaves compared to stem and seeds. The amount of dopamine and noradrenalin obtained from leaves varies according to the solvents used in the extraction process, suggesting that the levels of these compounds are dependent on the solvents used during the extraction process [20]. Oleraceins A, B, C, D, and E are cyclodopa alkaloids isolated from this plant [21] and several analytes such as (3R)-3,5-bis(3-methoxy-4-hydroxyphenyl)-2,3-dihydro-2(1H)-pyridinone and 1,5-dimethyl-6-phenyl-1,2-dihydro-1,2,4-triazin-3(2H)-one display cytotoxic activities against human cancer cells [22].

Portulaca oleracea is also an excellent source of omega-3 fatty acids, which is usually present in oil and fat of fishes but not normally found in plants. Omega-3 fatty acids play an important role in the enhancement of immune function [23] and prevention and treatment of hypertension, coronary artery disease, cancer, and other inflammatory and autoimmune disorders [24]. It includes α-linolenic acid and linoleic acid, which are essential for normal growth, health promotion, and disease prevention in humans. Polysaccharides found inPortulaca oleracea are potential therapeutic agents for the treatment of diabetes mellitus owing to their modulation of blood lipids, metabolism, and decrease of blood glucose. Portulaca oleracea contains monoterpenes such as portulosides A and B, diterpenes such as portulene, and β-amyrin type triterpenoids [1, 25]; in addition, vitamins have also been isolated from the leaves of this plant. It contains the highest content of vitamin A which is a natural antioxidant playing an important role in vision, maintaining healthy mucus membranes and protecting against lung and oral cavity cancers among green leafy vegetables. This plant also contains ascorbic acid, α-tocopherol, and B-complex vitamins, for example, niacin, pyridoxine, and riboflavin [26]. Furthermore it is rich in minerals like phosphorus, manganese, icon, calcium selenium [3], and the amino acids isoleucine, proline, leucine, lysine, phenylalanine, methionine, cystine, valine, threonine, and tyrosine [2]. Many other constituents have also been isolated from this plant, such as β-carotene, glutathione, melatonin, portulacerebroside A, catechol, and bergapten.

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3. Pharmacology

Over the past decades, numerous researchers have investigated the pharmacological activities of Portulaca oleracea. This review provides a comprehensive summary of the main pharmacological properties which are presented below.

3.1. Neuroprotective Activity

Administration of Portulaca oleracea can scavenge free radicals and antagonize rotenone-induced neurons apoptosis, dopamine depletion, and complex-I inhibition in striatum of rats, suggesting that Portulaca oleracea may be a potential neuroprotective candidate against Parkinson’s disease [23]. The extract of Portulaca oleracea (EP) protects nerve tissue/cells from hypoxic damage probably by elevation of glycolysis, EPO, and hypoxia inducible factor-1 expression levels [27]. The ethanol extract decreases the activity of caspase-3 in neuron whilst reducing serum levels of neuron specific enolase in hypoxia mice and the pathological damages caused by hypoxia. In these studies, an increase in the neuron viability and an induction in the mRNA and protein expression of endogenous erythropoietin have also been reported. Thus, the stabilization of hypoxia inducible factor-1 α expression is associated with the neuroprotective effects of EP against hypoxia injury by eliciting endogenous erythropoietin expression [28]. β-Cyanin evidently inhibits D-galactose-induced neurotoxicity in mice, which at the doses of 50 and 100 mg/kg upregulates the activities of superoxide dismutases, catalase, glutathione reductase, and glutathione peroxidase, whilst reducing the level of the lipid peroxidation product malondialdehyde in the brain of D-galactose-treated mice. When compared to vitamin C, β-cyanin play a more pronounced effect on alleviating cognition deficits in mice [29]. The total alkaloidal extracts from 31 traditional Chinese Herbal Medicines were tested for their acetylcholinesterase (AChE) inhibitory activities by Ellman’s method and modified TLC bioautographic assay. As a result, the alkaloidal extract of Portulaca oleracea significantly inhibited AChE activity at a final concentration of 100 μg/mL with the IC50 value of 29.4 μg/mL. The use of AChE inhibitors has been a promising treatment strategy for Alzheimer’s disease (AD); therefore, Portulaca oleraceamay be an effective agent for the prophylaxis and treatment of AD [30].

3.2. Antidiabetic Activity

Portulaca oleracea attenuates body weight, serum free fatty acids, and hyperinsulinemia. It also increases insulin sensitivity and ameliorates impaired glucose tolerance and lipid metabolism in rats with type 2 diabetes mellitus induced by injection of streptozotocin (25 mg/kg) and feeding of high calorie forage, suggesting that Portulaca oleracea alleviates insulin resistance [31]. Administration of the seeds powder (5 g × 2/day) increases high density lipoprotein cholesterol (HDLC) and albumin, while lowering the levels of serum total cholesterol, triglycerides, low density lipoprotein cholesterol (LDLC), liver gamma glutamyl transaminase (GGT), alanine transaminase (ALT), aspartate transaminase (AST), total and direct bilirubin, fasting and postprandial blood glucose, insulin, body weight, and body mass index in type 2 diabetic subjects. There were no differences in these results compared to the data obtained with metformin treatment (1500 mg/day) except for LDLC, HDLC, and alkaline phosphatase (ALP) levels, suggesting that Portulaca oleracea seeds are valuable and effective as an adjunctive and alternative therapy for the treatment of type 2 diabetes mellitus [32].

The aqueous extract of Portulaca oleracea also prevents diabetic vascular inflammation, hyperglycemia, and diabetic endothelial dysfunction in type 2 diabetic db/db mice, suggesting its protective role against diabetes and related vascular complications [33]. The crude polysaccharide extract of this plant also lowers blood glucose and modulates the metabolism of blood lipids and glucose in alloxan-induced diabetic mice [34], whilst decreasing the levels of total cholesterol, triglycerides, and fasting blood glucose in type 2 diabetic mice [32].

3.3. Antioxidant Activity

The antioxidant property of Portulaca oleracea is attributed to its constituents, such as gallotannins, omega-3 fatty acids, ascorbic acid, α-tocopherols, kaempferol, quercetin, and apigenin [8, 16, 17]. The single cell gel electrophoresis assay (comet assay), which is an simple, rapid, and inexpensive method for measuring DNA strand breaks, confirmed that the aqueous extract significantly alleviated hydrogen peroxide-induced oxidative DNA lesions in human lymphocytes, whereas the ethanolic extract had no effects, which may be associated with the antioxidant constituents contained in the aqueous extract [35]. The aqueous extract decreases high fat diet-elicited oxidative damage by modulating blood and liver antioxidant enzyme activities, elevating leptin/β-actin and liver PPAR a/β-actin and inhibiting the protein expression of p-PERK and the FAS mRNA expression of liver and spleen in mice [9]. In another study, the aqueous extract at a concentration range of 100, 150, 200, and 400 μg/mL and the ethanolic extract at a range of 1200 and 1800 μg/mL, respectively, exerted cytoprotective effects on 2,2′-azobis hydrochloride-induced hemolytic damages of RBCs in a concentration-dependent manner [36].

3.4. Anticancer Activity

Polysaccharides from Portulaca oleracea display several biological activities, such as anticancer, antioxidation, anti-inflammation, and immunity enhancing properties [37–40]. Polysaccharides evidently scavenge the accumulation of free radicals and modulate immunity functions of rats with ovarian cancer [41]. Sulfated derivatives of POP, a water-soluble polysaccharide isolated fromPortulaca oleracea, have a suppressive effect on the growth of HeLa and HepG2 cells in vitro, suggesting that the sulfation of POP increases the cytotoxicity in tumor cells [42]. In addition to polysaccharides, other bioactive compounds such as cerebrosides, homoisoflavonoids, and alkaloids also showin vitro cytotoxic activities against human cancer cell lines. Portulacerebroside A stimulates human liver cancer HCCLM3 cell apoptosis via the activation of the p38 MAPK- and JNK-triggered mitochondrial death pathway [43] and 2,2′-dihydroxy-4′,6′-dimethoxychalcone is more active against cell line SGC-7901 with an IC₅₀ value of 1.6 ug/mL than mitomycin C which has an IC₅₀ value of 13.0 ug/mL. Portulacanones B is active against SGC-7901 cell lines with an IC₅₀ value of 16.2 ug/mL, which is very close to the value obtained with mitomycin C. 2,2′-Dihydroxy-4′,6′-dimethoxychalcone is moderately active against K-562 cells with an IC₅₀ value of 24.6 ug/mL and portulacanones B–D show selective cytotoxic activity against SF-268 and/or NCI-H460 cells with IC₅₀ values of 14.3–20.1 ug/mL [18]. N-trans-Feruloyltyramine, (7′R)-N-feruloylnormetanephrine, 1,5-dimethyl-6-phenyl-1,2-dihydro-1,2,4-triazin-3(2H)-one, and (3R)-3,5-bis(3-methoxy-4-hydroxyphenyl)-2,3-dihydro-2(1H)-pyridinone have weak bioactivities against K562 with IC₅₀ values of 222.77, 66.94, 90.09, and 41.52 umol/L, respectively, and moderate bioactivities against A549 with IC₅₀ values of 28.80, 21.76, 24.54, and 37.20 umol/L, respectively [22]. These studies demonstrate that Portulaca oleracea has a potential application in the treatment of cancer.

3.5. Antimicrobial

Portulaca oleracea possesses antibacterial, antifungal, and antiviral activities as revealed by its antifungal effect against dermatophytes of the generaTrichophyton [44]. A pectic polysaccharide isolated from the aerial part of this plant displays antiherpes property against simplex virus type 2 which is due to the inhibition of virus penetration and not virus adsorption [45]. A 70% methyl alcohol extract of Portulaca oleracea shows antibacterial activity against the Gram-negative stains: Escherichia coli, Pseudomonas aeruginosa, andNeisseria gonorrhea with inhibition zones of 14, 15, and 15 mm, respectively, and the Gram-positive strains: Staphylococcus aureus, Bacillus subtilis, andStreptococcus faecalis with inhibition zones of 13, 14, and 15 mm, respectively, as well as antifungal activity against Candida albicans with inhibition zone of 12 mm [1].

3.6. Anti-Inflammatory Activity

Pretreatment with the aqueous extract of Portulaca oleracea inhibits tumor necrosis factor- (TNF-) α-induced production of intracellular reactive oxygen species (ROS) and overexpression of intercellular adhesion molecule- (ICAM-) 1, vascular cell adhesion molecule (VCAM)-1, and E-selectin in human umbilical vein endothelial cells (HUVECs) in a dose-dependent manner. This extract also suppresses the translocation of nuclear factor κB (NF-κB) p65 to the nucleus, TNF-α-induced NF-κB binding, and the degradation of inhibitor molecule (IκB)α. Furthermore, an inhibition in the adhesion of HL-60 cells to TNF-α-induced HUVECs and TNF-α-induced mRNA expression of interleukin- (IL-) 8 and monocyte chemoattractant protein- (MCP-) 1 is also observed. The aqueous extract of Portulaca oleracea may also play an important role in the suppression of the vascular inflammatory process related to the development of atherosclerosis [46].

3.7. Antiulcerogenic Activity

Aqueous and ethanolic extracts of Portulaca oleracea at 0.8 g/kg and 1.4 g/kg, respectively, can reduce the severity of HCl-induced gastric ulcers in a dose-dependent manner; this is comparable to the effect observed with sucralfate 0.1 g/kg. In addition, the aqueous extract (0.56 and 0.8 g/kg) and the ethanolic extract (0.8 and 1.4 g/kg) display suppression of lesions induced by absolute ethanol. The oral and intraperitoneal doses of both extracts dose-dependently increase the pH of gastric juice in mice with pylorus ligation. Thus, Portulaca oleracea holds great promise as an effective therapeutic agent for gastrointestinal diseases due to its gastroprotective activity [7].

3.8. Hepatoprotective Activity

Intraperitoneal administration of CCl₄ elicits liver injury in rats, which notably upregulates the levels of total bilirubin and serum hepatic marker enzymes, including glutamate pyruvate transaminase (GPT) and glutamate oxaloacetate transaminase (GOT). A 70% alcohol extract of Portulaca oleracea significantly reverses the increase in hepatic marker enzymes and total bilirubin levels, confirming the hepatoprotective activity of this plant [1].

3.9. Other Activities

The ethanol extract from Portulaca oleracea at a concentration range of 100, 200, and 400 mg/kg, respectively, displays a dose-dependent effect in prolonging the survival time of mice in hypoxic models, including closed normobaric hypoxia and potassium cyanide or sodium nitrite toxicosis. This extract also enhances the activities of phosphofructokinase, pyruvate kinase, and lactate dehydrogenase in glycolysis and the level of adenosine triphosphate of mouse cortices in hypoxia models [12]. The preliminary wound healing activity of Portulaca oleracea has been appraised in Mus musculus JVI-1 and it has been shown that a fresh crude extract significantly accelerates the wound healing course by the stimulation of wound contraction and downregulation of the surface area of the excision wound [10]. Portulaca oleracea also has the ability to accumulate Se even at the shortest time span of 42 days, and hence it can perform the dual functions of preventing the occurrence of Se deficiency linked diseases such as Keshan and Kashin-Beck diseases [47].

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4. Conclusion

Portulaca oleracea is of considerable importance to the food industry and also possesses a wide spectrum of pharmacological properties such as neuroprotective, antimicrobial, antidiabetic, antioxidant, anti-inflammatory, antiulcerogenic, and anticancer activities, which are associated with its diverse chemical constituents, including flavonoids, alkaloids, polysaccharides, fatty acids, terpenoids, sterols, proteins, vitamins, and minerals.

Although bioactivities of extracts or compounds isolated from Portulaca oleracea are substantiated by using in vitro and in vivo studies including animal models and cell culture studies, the mechanisms of action have not been addressed. Hence, more mechanistic studies are required before Portulaca oleracea can be considered for further clinical use. This review concludes thatPortulaca oleracea is an edible and a medicinal plant which is important to the food industry and may also have a significant role to play in health care provided that adequate studies are conducted.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (nos. 81173462 and 81102774), National Science and Technology Major Projects for Major New Drugs Innovation and Development (2014ZX09J14106-06c), and the Open Research Fund of State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources.

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Conflict of Interests

The authors have declared that there is no conflict of interests.

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Authors’ Contribution

Yan-Xi Zhou and Hai-Liang Xin contributed equally to this work.

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